Have questions? We're here.
Panama's turquoise waters

Portobelo Small Ship Cruises

Travel made your way ™
Talk with an expert
Build your ideal Panama trip. Call 1.406.541.2677
Start Planning My Trip
Talk with an expert
Experience the allure of Panama and its surrounding wonders with Adventure Life's selection of 5 small ship cruises for 2026. Join us on a cruise journey through the enchanting Caribbean coast, ancient colonial cities, and lush rainforests. From exploring the UNESCO-listed streets of Cartagena de Indias and diving into the protected waters of Barbados to meeting the Indigenous people of Guna Yala and marveling at the colonial architecture of Willemstad, each moment is filled with cultural and natural marvels. Engage in wildlife viewing, snorkeling in crystal-clear waters, and immerse yourself in the rich biodiversity of the region. With activities suitable for all travelers, this adventure offers a relaxed pace to discover the captivating nature and history of Panama and its surroundings. Don't miss this opportunity to embark on a seamless journey through this tropical paradise. Contact one of Adventure Life's tour specialists for help planning your next unforgettable trip.
Filter (5 Results)
  • Start Date
    OR, More specific start
  • Length
    to
  • Price
    to
  • Activity Levels
  • Experiences
  • Activities
  • Ships
  • Destinations
    • Portobelo
Guests explore by zodiac cruise in Portobelo, Panama
from $6,150
EXPLORE

The Panama Canal, Pearl Islands and Darien Jungle

Southbound - 8 Day Itinerary aboard National Geographic Quest
  • Transit the Panama Canal
  • Explore Darien Jungle
  • Visit Portobelo Forts
  • Snorkel Pearl Islands
Starts / Ends
Panama City / Balboa
Activities
Village Visits, Snorkeling, Kayaking, Stand Up Paddle Boarding, Hiking, Wildlife Viewing, Urban Exploration
Activity Level
Variable
Embark on an 8-day Panama Canal cruise to the Pearl Islands and Darien Jungle aboard the National Geographic Quest. Transit the legendary Panama Canal, meet the Emberá people in Playa Muerto, spot wildlife in Punta Patiño, and snorkel the clear waters of the Pearl Islands, including Isla del Rey and Isla Pacheca.
Cruise Details
0
Balboa
from $3,150
EXPLORE

Panama to Aruba

12 Day Itinerary aboard Star Clipper
  • Transit the Panama Canal locks
  • Walk colonial Balboa streets
  • Explore forts in Portobelo
  • Visit San Blas and Guna villages
  • See Cartagena and Santa Marta
Starts / Ends
Balboa / Oranjestad
Activities
Archaeological Site Visits, Small Ship Sailing, Local Market Visits
Activity Level
Variable
Sail the Panama Canal on a 10-day Star Clippers cruise through Central America. Begin in Balboa, then transit the Panama Canal and see the locks in action. Explore Spanish forts in Portobelo, meet the Guna people in the San Blas Islands, and discover Colombia’s coastal cities of Cartagena and Santa Marta. Enjoy scenic days under sail.
Cruise Details
0
Sunset over Cartagena, Colombia
from $6,450
Save 20%
EXPLORE

Panama and Colombia: Exploring the Caribbean Coast

Panama to Cartagena - 8 Day Itinerary aboard National Geographic Quest
  • Transit the Panama Canal
  • Meet Indigenous people of Guna Yala
  • Look for unique tropical wildlife
  • See colonial architecture
Starts / Ends
Panama City / Cartagena
Activity Level
Variable
Discover an astonishing trove of natural and cultural treasures as you navigate the Caribbean coasts of Panama and Colombia on this 8-day cruise aboard the National Geographic Quest. Sail from Panama City to Cartagena, with stops in Portobelo, Guna Yala, Archipelago, and more.
Cruise Details
0
Tranquil shores and swaying palms welcome you to Cayman Brac
from $4,240
EXPLORE

Panama to Jamaica

Balboa - Montego Bay - 15 Day Itinerary aboard Star Clipper
  • Explore Balboa’s architecture
  • Transit Panama Canal’s locks
  • Discover Portobelo’s Spanish forts
  • Tour Puerto Limon’s markets
Starts / Ends
Balboa / Isla de Providencia
Activity Level
Variable
Join a 15-day cruise from Balboa to Montego Bay aboard the Star Clippers, sailing through the Panama Canal and exploring cultural gems like Portobelo and Puerto Limon. Relax at sea and visit beautiful beaches in Bocas del Toro and the diving hotspots of George Town and Cayman Brac before concluding your journey in Jamaica.
Cruise Details
0
Mountains by the ocean in St Lucia
from $8,490
Save 10%
EXPLORE

Panama, Colombia & Caribbean Islands

Colon to Fort-de-France - 13 Day Itinerary aboard Le Champlain
  • Sail through the Central America.
  • See San Blas, Bonaire & Grenadines
  • Experience swim and snorkel.
  • Learn traditions of the Kuna people
  • Dive with an experienced instructor
Starts / Ends
Colon / Fort de France
Activities
Land & Sea Exploration
Activity Level
Variable
Join Le Bellot for an exceptional 13-day cruise sailing from Colón to Fort-de-France. This itinerary gives you the opportunity to appreciate the richness and diversity of Afro-Caribbean cultures, an azure blue sky, and white-sand beaches. Visit stunning ports, including Portobelo, Cartagena, Santa Marta, Mayreau Island, and Soufriére.
Cruise Details
0
1-5 of 5 Results
  • 1

Panama Travel Guide

Top Panama Travel Destinations

Panama Trips by Departure Date

Top Experiences in Panama

Panama Trips by Duration

Panama Trips by Activity

More Reasons

Why Travel With Adventure Life

All News

Recognized By

Rachel Brouwer employee head shot
Rachel B
Plan My Trip
We love travel, talk with an expert 1.800.344.6118