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Top Panama Canal Cruises & Trips

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Explore these 8 top Panama Canal cruises for 2025 and 2026. Some of the most popular activities on our Panama Canal trips include Wildlife Viewing, Archaeological Site Visits, Snorkeling, Village Visits, and Local Market Visits. Discover with your expert local English-speaking guides who will show you the hot spots and the off-the-beaten-path hidden gems. We work with only the best small ships that carry under 500 fortunate guests, and we can give you unbiased advice to match you with the perfect ship and perfect cruise for your next vacation. Our Panama Canal cruises start from $4,240 for cruises of 8 to 15 days. Contact one of Adventure Life's Panama Canal cruise specialists for help planning a seamless trip.
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Explore beautiful Costa Rica
from $6,420
EXPLORE

Panama and Costa Rica by Sea: The Natural Wonders of Central America – with Smithsonian Journeys

Colon - Puntarenas - 8 Day Itinerary aboard Le Champlain
  • Discover San Blas
  • Experience Panama Canal
  • Explore Fuerte Amador
  • Visit Darien National Park
Starts / Ends
Colon / Puntarenas
Activity Level
Variable
Join this 8-day cruise aboard Le Champlain to explore the natural wonders and cultural heritage of Panama and Costa Rica, including the white sands of Holandes Cayes, the iconic Panama Canal, and Panama City's historic Old Quarter.
Cruise Details
0
from $9,230
EXPLORE

Secrets of Central America

Colón - Puntarenas - 11 Day Itinerary aboard Le Champlain
  • Discover National Parks
  • Sail through the Panama Canal
  • Encounter with Emberas tribe
  • Visit San Blas archipelago
Starts / Ends
Puerto Caldera / Colon
Activity Level
Variable
Join this 11-day Secrets of Central America cruise and explore Panama and Costa Rica, starting at San Lorenzo’s Fort and traveling from the Atlantic to the Pacific. Visit the San Blas Islands, the Pearl Islands, Darien National Park, and cross the Panama Canal. Meet local communities, and discover the biodiversity of Rio Esquinas and Curú Nature Reserve.
Cruise Details
0
Boats Moored to the Quay at Bridgetown Harbour
from $4,350
EXPLORE

Barbados to Panama

15 Day Itinerary aboard Royal Clipper
  • Explore Bridgetown, Barbados
  • Enjoy Grenada's unique aromas
  • Discover Dutch colonial Curacao
  • Transit the historic Panama Canal
Starts / Ends
Bridgetown / Balboa
Activity Level
Variable
Starting at the Caribbean port of Bridgetown, this 15-day cruise aboard the Royal Clipper sails through the turquoise Caribbean waters en route to the Panama Canal, visiting Grenada, Bonaire, Curacao, Aruba, and Colombia along the way. Explore the tropical jungles, snorkel in vibrant reefs, immerse yourself in tribal culture, and marvel at the Panama Canal.
Cruise Details
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Trekking through Corcovado National Park in Costa Rica.
from $7,315
EXPLORE

Costa Rica and the Panama Canal

San Jose - Panama - 8 Day Itinerary aboard National Geographic Quest
  • Observe animals in their habitat
  • Kayak through magical mangroves
  • Transit the historical Panama Canal
  • Explore Gulf of Panama beaches
Activities
Horseback Riding, Kayaking
Activity Level
Variable
Discover Costa Rica & Panama on this wonderful 8-day expedition cruise aboard the National Geographic Quest. Venture into remote wilderness and hike among monkeys, sloths, and tropical birds, explore idyllic islands, snorkel over a vibrant coral reef, and take an expedition landing craft cruise through mangroves.
Cruise Details
0
The vivid colors of the San Blas Islands
from $4,240
EXPLORE

Barbados to Panama

Bridgetown - Balboa - 15 Day Itinerary aboard Star Clipper
  • Explore Bridgetown’s heritage
  • Discover St. George’s coastal views
  • Admire Kralendijk’s marine life
  • Wander Willemstad’s streets
Starts / Ends
Bridgetown / Balboa
Activities
Wildlife Viewing, Small Ship Sailing, Local Market Visits, Archaeological Site Visits
Activity Level
Variable
Set sail on a 15-day cruise with Star Clipper from Bridgetown, Barbados, exploring the Caribbean’s rich culture and history, ending in Balboa, Panama. Visit stunning destinations like Tobago Cays, Grenada, and the San Blas Islands, and experience the Panama Canal.
Cruise Details
0
Crossing a stream on Osa Peninsula
from $11,295
EXPLORE

Costa Rica & Panama Canal

Costa Rica - Colombia - 12 Day Itinerary aboard Greg Mortimer
  • Explore Costa Rica's wildlife
  • Discover vibrant bird species
  • Learn about the Emberá tribe
  • Cross the Panama Canal
  • Visit Curú National Wildlife Refuge
Starts / Ends
San Jose / Colon
Activities
Stand Up Paddle Boarding, Snorkeling, Village Visits, Photography Seminars, Scuba Diving, Whale Watching
Activity Level
Variable
Embark on a 12-day Costa Rica & Panama Canal Cruise with travel photographer Richard I'Anson. Explore Costa Rica's rainforests, and Panama's coral reefs, connect with the Emberá tribe, and delve into Panama Canal's history.
Cruise Details
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The vivid colors of the San Blas Islands
from $4,350
EXPLORE

Panama to Antigua

15 Day Itinerary aboard Royal Clipper
  • Explore Balboa’s colonial charm
  • Transit Panama’s iconic canal
  • Discover San Blas culture
  • Enjoy Aruba’s clear waters
Starts / Ends
Balboa / St. John's
Activity Level
Variable
Set sail on a 15-day Royal Clipper cruise from Balboa, Panama, featuring a full Panama Canal transit and visits to the San Blas Islands, Cartagena, and the Caribbean gems of Aruba, Curacao, and Bonaire. Experience lush Grenada and volcanic St. Lucia, and finish your journey in Antigua, all while enjoying elegant sailing and stunning island views.
Cruise Details
0
Zapatilla Cay, Panama
from $6,741
Save 20%
EXPLORE

Panama and Colombia: Exploring the Caribbean Coast

8 Day Itinerary aboard National Geographic Quest
  • Transit the Panama Canal
  • Meet Indigenous people of Guna Yala
  • Look for unique tropical wildlife
  • See colonial architecture
Starts / Ends
Panama City / Cartagena
Activity Level
Variable
Discover an astonishing trove of natural and cultural treasures as you navigate the Caribbean coasts of Panama and Colombia on this 8-day cruise aboard the National Geographic Quest. Sail from Panama City to Cartagena, with stops in Portobelo, Guna Yala, San Bernardo Archipelago, and more.
Cruise Details
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