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Missouri River Cruises

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Explore the wonders of the Mississippi River on one of Adventure Life's 5 river cruises in Missouri in 2025. Navigate through the heart of the United States on a journey filled with cultural richness and historical significance. Sail past charming river towns, lush forests, and iconic landmarks, immersing yourself in the beauty of the river's landscapes. Discover the vibrant music scene, indulge in delicious local cuisine, and explore the fascinating heritage of the region. From wildlife viewing to wine tasting, there is something for everyone on these river cruises. Join us on a trip to Missouri and contact one of our river cruise experts for help planning your next seamless trip.
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    • Missouri
View the iconic arch when you visit St. Louis, gateway to the west
$12,999
EXPLORE

America’s Great River

St. Paul to New Orleans - 15 Day Itinerary aboard Viking Mississippi
  • Explore St. Louis' arts scene
  • Enjoy American music styles
  • Learn Civil War history
  • Experience New Orleans' culture
  • Visit the Quad Cities
Starts / Ends:
St. Paul / New Orleans
Activities:
Archaeological Site Visits, River Cruises, Village Visits
Activity Level:
Variable
Discover the history, natural beauty, and distinctive regional cultures of America's great river, the mighty Mississippi, on this 15-day cruise aboard Viking Mississippi. Set sail from St. Paul, Minnesota, and venture south toward New Orleans, Louisiana. Along the way, visit small towns and …
Cruise Details
0
Mississippi River, St. Paul Minnesota
$5,545
Savings
EXPLORE

Upper Mississippi River

St. Louis, MO to St. Paul, MN - 9 Day Itinerary aboard American Melody
  • Explore the culture of St. Louis
  • See Mark Twain's hometown, Hannibal
  • Witness wildlife and nature
  • Admire local artwork in Red Wing
Starts / Ends:
St. Louis / Red Wing
Activities:
Archaeological Site Visits, River Cruises, Urban Exploration, Village Visits
Activity Level:
Variable
Embark on a cruise along the Upper Mississippi River, exploring St. Louis, Alton, Hannibal, Muscatine, Dubuque, Winona, and Red Wing. Visit Mark Twain's home, witness diverse landscapes, and enjoy expert-guided tours. Adapt to the river's character as you relax on lounges, decks, or …
Cruise Details
0
Vibrant Sunset with St. Paul City Skyline and Mississippi Riverfront
$11,755
Savings
EXPLORE

Grand Heartland Cruise

Minnesota - Louisiana - 16 Day Itinerary aboard American Serenade
  • Visit mansions and art galleries
  • See the Gateway Arch and St. Louis
  • Visit Natchez’s antebellum homes
  • Experience Memphis' musical legacy
Starts / Ends:
St. Paul / New Orleans
Activities:
Village Visits
Activity Level:
Variable
Embark on a 16-day cruise aboard American Serenade and begin by exploring St. Paul's art galleries and historic Summit Avenue. In La Crosse, enjoy Riverside Park and panoramic views from Grand Dad’s Bluff. Discover Dubuque, with its Victorian mansions and the Mississippi River Museum …
Cruise Details
0
The upper Mississippi region
$6,999
EXPLORE

America’s Heartland

St. Louis to St. Paul - 12 Day Itinerary aboard Viking Mississippi
  • Discover history of the Mississippi
  • Explore Dubuque, Iowa
  • Experience Mississippi river towns
  • Admire local artisan work
Starts / Ends:
St. Louis / St. Paul
Activities:
Archaeological Site Visits, River Cruises, Village Visits
Activity Level:
Variable
On this enlightening journey on the Upper Mississippi, hear stories of pioneers and the Lewis and Clark Expedition; walk in the footsteps of Mark Twain; and learn about the Norwegian migration. Enjoy the view as your ship navigates through the river’s intricate lock system. Experience the …
Cruise Details
0
Mississippi River, St. Paul Minnesota
$4,530
Savings
EXPLORE

Upper Mississippi River

St. Louis, MO to St. Paul, MN - 9 Day Itinerary aboard American Heritage
  • Explore the culture of St. Louis
  • See Mark Twain's hometown, Hannibal
  • Witness wildlife and nature
  • Admire local artwork in Red Wing
Starts / Ends:
St. Louis / Red Wing
Activities:
Archaeological Site Visits, River Cruises, Urban Exploration, Village Visits
Activity Level:
Variable
Embark on a cruise along the Upper Mississippi River, exploring St. Louis, Alton, Hannibal, Muscatine, Dubuque, Winona, and Red Wing. Visit Mark Twain's home, witness diverse landscapes, and enjoy expert-guided tours. Adapt to the river's character as you relax on lounges, decks, or …
Cruise Details
0
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