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St. Louis
is a major
Mississippi River
port and city in Missouri – right in the center of the
United States
. Most of our river cruises offered will start in
Minneapolis
and
St. Louis
itself and head south, or vice versa. While at the city you will likely visit the Gateway Arch and the museum located at the Gateway Arch round out and depending on your specific cruise you will visit parks, ranches, and more. After a day full of adventure you will head south to
Memphis
,
Vicksburg
,
Baton Rouge,
and
New Orleans
.
Contact our travel specialists to start planning your ideal river cruise today!
All St Louis Cruises
5 Best St Louis River Cruises for 2025-2026
All St Louis Cruises
Upper Mississippi River
9 Days from
$
5,545
Explore the segment of the Mississippi River on this 9-day cruise from St. Louis to Minneapolis American Melody. Begin in St. Louis, Missouri, and through Alton, Hannibal, Muscatine, Dubuque, Winona, and Red Wing. Visit Mark Twain's boyhood home, explore historic towns, and marvel at the diverse landscapes.
EXPLORE
0
Grand Heartland Cruise
16 Days from
$
12,620
Embark on a 16-day Mississippi River cruise from Minnesota to Louisiana aboard American Serenade, exploring St. Paul to New Orleans with stops in La Crosse, Dubuque, Davenport, Hannibal, St. Louis, Memphis, Vicksburg, and Natchez. Enjoy onboard activities, stunning scenery, and experiences like the Mark Twain Boyhood Home and more.
EXPLORE
0
Complete Mississippi River
23 Days from
$
15,640
Discover the Mighty Mississippi on a 23-day cruise covering 10 states aboard American Melody. Immerse in history, culture, and cuisine from New Orleans to Minneapolis, exploring charming ports along the way.
EXPLORE
0
America’s Great River
15 Days from
$
12,999
Cruise America's great river on this 15-day itinerary aboard Viking Mississippi. Journey from St. Paul, Minnesota to New Orleans, Louisiana and explore highlights of the mighty Mississippi River. Along the way, visit historic ports such as St. Louis, Memphis, Baton Rouge, and more.
EXPLORE
0
Upper Mississippi River
9 Days from
$
4,530
Explore the segment of the Mississippi River on this 9-day cruise from St. Louis to Minneapolis American Heritage. Begin in St. Louis, Missouri, and through Alton, Hannibal, Muscatine, Dubuque, Winona, and Red Wing. Visit Mark Twain's boyhood home, explore historic towns, and marvel at the diverse landscapes.
EXPLORE
0
All Mississippi River Articles
Mississippi River Travel Guide
How to Choose the Perfect Mississippi River Cruise for You
The Mississippi is such a long river, winding through a huge variety of destinations, that it's important to prioritize what you want to see and do on your cruise to help choose the best one for you. These are some of the most important factors to consider when selecting your cruise:
0
The Best Times to Take a Mississippi River Cruise
The best time to cruise the Mississippi River is during the months of spring (March, April, May) or fall (September, October, November) to avoid the extreme hot and cold temperatures in summer and winter. The Mississippi is so long that giving overall advice can be difficult, as the temperatures in Minnesota are much colder than those in Louisiana on the same day. Additionally, there is a higher chance of flooding in the spring and a potential need to reroute or reschedule.
0
Top Things to See and Do on a Mississippi River Cruise
On a Mississippi River cruise, there’s no excuse for boredom: you'll float past roaring waterfalls, dams, and scenic river bluffs, and explore historical towns along the banks of the mighty river. These are just a few of the highlights you'll experience on a Mississippi River cruise.
0
Culture and History of the Mississippi River
Much of American history and culture has bloomed on and near the river. Playing a major role in the Civil War, and WWI, as well as American cultural classics like The Adventures of Tom Sawyer and The Adventures of Huckleberry Finn written by the sorts of Mark Twain, who could be easily considered in the top 3 most influential American writers of all time. Over fifty thousand years ago the Central United States was covered in water by an inland sea that drained south through what is known nowadays as the Mississippi River.
0
Upper Mississippi vs. Lower Mississippi River Cruises
Unless you have over two weeks to spare and can cruise the entire Mississippi River, you will have to make the hard decision of whether to cruise the Upper or Lower Mississippi. Each section of this vast river can see wildly different weather at similar times of year, so the ideal time to visit will depend on where you plan to go. The overall experience between north and south also varies, with the north having more wildlife and scenery while the south offers more cultural experiences and history. The Mississippi tributaries like the Ohio, Tennessee, and Illinois Rivers offer an alternative, abbreviated Mississippi River experience worth considering.
0
Top 10 Mississippi River's Cruise Ports
Below are our favorite Mississippi River cruise ports in order from north to south. Mississippi ports range from big cities like New Orleans and St. Louis to small historical towns like Mark Twain’s Hannibal and historical Vicksburg, Mississippi.
0
Top Mississippi River Travel Destinations
Baton Rouge
Bettendorf
Cape Girardeau
Louisiana
Memphis
Minnesota
Mississippi
New Orleans
North America
St. Louis
Tennessee
United States
Vicksburg
Mississippi River Trips by Departure Date
2025 Mississippi River trips
(16)
2026 Mississippi River trips
(11)
April 2025
(7)
October 2025
(6)
November 2025
(7)
Mississippi River Trips by Duration
8 day trips
(3)
9 day trips
(8)
12 day trips
(3)
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