10 Best Mississippi River Cruises for 2025-2026

Top Mississippi River Cruise Deals for 2025 and 2026

Trip Name	Save	From	Days	Next Departure	Summary
Historic Mississippi River Cruise	Savings	$3475	8	Mar 29, 2025	The American Heritage hosts this 8-day Mississippi River cruise from New Orleans. Explore historic plantations, Civil War sites, and charming towns. … 0
Lower Mississippi River Cruise	Savings	$5190	9	Dec 6, 2024	Experience a 9-day cruise aboard American Symphony from Memphis to New Orleans, discovering historic sites, Civil War stories, and charming towns … 0
Music Cities Cruise	Savings	$4840	9	Apr 22, 2025	Set sail on a 9-day cruise on the American Symphony from Memphis to Nashville, traversing the Mississippi, Ohio, and Cumberland rivers—Immerse in … 0
Upper Mississippi River	Savings	$5545	9	Jul 18, 2025	Explore the segment of the Mississippi River on this 9-day cruise from St. Louis to Minneapolis American Melody. Begin in St. Louis, Missouri, and … 0
Upper Mississippi River	Savings	$4530	9	Sep 5, 2025	Explore the segment of the Mississippi River on this 9-day cruise from St. Louis to Minneapolis American Heritage. Begin in St. Louis, Missouri, and … 0
Complete Mississippi River	Savings	$15640	23	May 23, 2025	Discover the Mighty Mississippi on a 23-day cruise covering 10 states aboard American Melody. Immerse in history, culture, and cuisine from New … 0
Lower Mississippi River Cruise	Savings	$4530	9	Jun 10, 2025	Experience a 9-day cruise aboard American Heritage from Memphis to New Orleans, discovering historic sites, Civil War stories, and charming towns … 0
Lower Mississippi River Cruise	Savings	$5190	9	Apr 4, 2025	Experience a 9-day cruise aboard American Melody from Memphis to New Orleans, discovering historic sites, Civil War stories, and charming towns along … 0

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Mississippi River Travel Guide

Top 10 Mississippi River's Cruise Ports

Below are our favorite Mississippi River cruise ports in order from north to south. Mississippi ports range from big cities like New Orleans and St. Louis to small historical towns like Mark Twain’s Hannibal and historical Vicksburg, Mississippi.

The Best Times to Take a Mississippi River Cruise

The best time to cruise the Mississippi River is during the months of spring (March, April, May) or fall (September, October, November) to avoid the extreme hot and cold temperatures in summer and winter. The Mississippi is so long that giving overall advice can be difficult, as the temperatures in Minnesota are much colder than those in Louisiana on the same day. Additionally, there is a higher chance of flooding in the spring and a potential need to reroute or reschedule.

Top Cruise Ports on the mighty Mississippi River
Where will your Mississippi River cruise take you? Mississippi River cruises immerse you in the culture and cuisine of the historic U.S. South.

Here are some of the most popular cruise ports where our Adventure Life Mississippi River cruises dock:

Get to Know New Orleans

While Baton Rouge might be the capital of Louisiana, the buzzing city of New Orleans could be considered the cultural capital of the state and one of the most exciting cities to visit in the American south while you enjoy your Mississippi River cruise - from the French Quarter to lively Bourbon Street, experience the true heart and flavor of Creole culture here, especially during JazzFest and their renowned Mardi Gras celebrations.

Get to Know Baton Rouge

Right on the Mississippi River, Baton Rouge - with its population at 225,000 people - is a great destination as you cruise through the state of Louisiana. In fact, Baton Rouge is the Louisiana state capital and home to the Magnolia Mound Plantation (including the French Creole House), the LSU Rural Life Museum, and the retired WWII destroyer USS Kidd, which is now a museum.

This is a great place to see Antebellum plantations and sites key in America's 19th century history.

Get to Know Vicksburg

Located in the western part of Mississippi, the city of Vicksburg is best known for its importance in the American Civil War as the location of a key battle. Now, at Vicksburg National Military Park, you can learn the history of this region as you explore the Old Court House, the National Cemetery and the restored USS Cairo gunboat. The Siege of Vicksburg (May 18, 1863 - July 4, 1863) marked a major victory for the Union army and a turning point in the Civil War as it gave them control of the Mississippi River.

Upper Mississippi River vs. Lower Mississippi River

The Upper Mississippi River stretches from its origins in Minneapolis, Minnesota down to its confluence with the Ohio River in Cairo, Illinois, also winding through Wisconsin, Iowa, and Missouri along the way.

The Lower Mississippi River originates in Illinois where the Mississippi and Ohio converge and flows downstream all the way to the Gulf of Mexico for about 1,000 miles (well, 990 miles to be exact!). It travels through Tennessee, Arkansas, Louisiana, and, of course, Mississippi.

Some of our cruises do go as far north as the Upper Mississippi River, but the majority of the itineraries spend most of their time visiting the destinations in "American's Heartland" on the Lower Mississippi River.

Upper Mississippi vs. Lower Mississippi River Cruises

Unless you have over two weeks to spare and can cruise the entire Mississippi River, you will have to make the hard decision of whether to cruise the Upper or Lower Mississippi. Each section of this vast river can see wildly different weather at similar times of year, so the ideal time to visit will depend on where you plan to go. The overall experience between north and south also varies, with the north having more wildlife and scenery while the south offers more cultural experiences and history. The Mississippi tributaries like the Ohio, Tennessee, and Illinois Rivers offer an alternative, abbreviated Mississippi River experience worth considering.

Top Things to See and Do on a Mississippi River Cruise

On a Mississippi River cruise, there’s no excuse for boredom: you'll float past roaring waterfalls, dams, and scenic river bluffs, and explore historical towns along the banks of the mighty river. These are just a few of the highlights you'll experience on a Mississippi River cruise.

How to Choose the Perfect Mississippi River Cruise for You

The Mississippi is such a long river, winding through a huge variety of destinations, that it's important to prioritize what you want to see and do on your cruise to help choose the best one for you. These are some of the most important factors to consider when selecting your cruise:

Culture and History of the Mississippi River

Much of American history and culture has bloomed on and near the river. Playing a major role in the Civil War, and WWI, as well as American cultural classics like The Adventures of Tom Sawyer and The Adventures of Huckleberry Finn written by the sorts of Mark Twain, who could be easily considered in the top 3 most influential American writers of all time. Over fifty thousand years ago the Central United States was covered in water by an inland sea that drained south through what is known nowadays as the Mississippi River.

Highlights of Mississippi River Cruises

A Mississippi River cruise offers a unique journey through America's heartland, combining scenic beauty, cultural richness, and historical significance. Here are some of the highlights you can experience:

Festive French Quarter in New Orleans: Discover the vibrant atmosphere, jazz music, and Creole cuisine in this iconic district.
Cajun Heritage in Baton Rouge: Explore the unique blend of French, Spanish, and African cultures that define Cajun heritage.
Civil War History at Vicksburg National Military Park: Visit this historic site to learn about one of the most pivotal battles of the Civil War.
Memphis BBQ and Graceland: Savor world-famous Memphis BBQ, tour Elvis Presley’s Graceland, and immerse yourself in the Delta Blues.
Steamboat Sailings with Diverse Wildlife: Enjoy traditional steamboat rides while spotting diverse wildlife along the riverbanks.
Mark Twain's Boyhood Home: Visit Hannibal, Missouri, to see the home of Mark Twain and delve into America’s literary history.
Bald Eagle Sightings: Get an up-close look at America’s national symbol, the bald eagle, in its natural habitat.
Gateway Arch in St. Louis: Marvel at this architectural wonder and explore the pioneering spirit of the Midwest.
Norwegian Cultural Experience at Vesterheim: Discover Norwegian-American heritage at this museum in Decorah, Iowa.
Intricate Locks and Dams of the Upper Mississippi: Learn about the engineering marvels that control the flow of the mighty Mississippi River.

FAQs: Mississippi River

How much does a Mississippi River cruise cost?

Mississippi River cruises cost between $1,300 and $5,000 per person, but the average price of a Mississippi River cruise is about $2,400 per person for a 9-day itinerary.

What is the best time of year to take a Mississippi River cruise?

The best time to cruise the Mississippi River is during the months of spring (March, April, May) or fall (September, October, November) to avoid the extreme hot and cold temperatures in summer and winter. The Mississippi is so long that giving overall advice can be difficult, as the temperatures in Minnesota are much colder than those in Louisiana on the same day. Additionally, there is a higher chance of flooding in the spring and a potential need to reroute or reschedule.

What destinations do Mississippi River cruises visit?

The top 10 destinations you can visit on a Mississippi River cruise are Red Wing by Minneapolis, Dubuque, Bettendorf, Hannibal, St. Louis, Cape Girardeau, Memphis, Vicksburg, Baton Rouge, and of course New Orleans!

Are Mississippi River cruises worth it?

Mississippi River cruises are a great value if you're hoping to really explore the whole region and get to know the local culture, food, and historic destinations that have shaped the mighty Mississippi. These cruises are definitely geared towards more mature audiences, so while inquisitive teens might enjoy these, they are crafted with adults in mind who enjoy activities like walking and biking tours, city & historic tours, nature experiences, and museums. These are not ideal for families with young children who are looking for a lot of onboard entertainment for kids of all ages.

What is the longest river in North America?

At 2,340 miles in length and up to 11 miles across at its widest point, the Mississippi River is the longest and most important river in North America, covering more than one million square miles and pulling in water from tributary rivers in 33 states. But even the mightiest river in North America has humble origins - in a babbling brook that you could easily skip across!

Why is it called the Mississippi?

In the US, every school-age child learns how to spell it - M-I-S-S-I-S-S-I-P-P-I. But where did the name come from? The name "Mississippi" actually owes its origins to the indigenous Anishinabe people (Ojibwe Indians), who called the river the "Messipi", meaning "Father of Waters" or "Big River."