Top Mississippi River Trips & Tours in April 2025

The American Heritage hosts this 8-day Mississippi River cruise from New Orleans. Explore historic plantations, Civil War sites, and charming towns. Immerse in the rich culture, cuisine, and music of the Deep South.

Experience a 9-day cruise aboard American Symphony from Memphis to New Orleans, discovering historic sites, Civil War stories, and charming towns along the Mississippi River. Experience rich history, music, and southern hospitality.

On this 8-day Mississippi Delta Explorer from New Orleans to Memphis aboard the Viking Mississippi, visit historic towns like Darrow, Natchez, and Vicksburg. Enjoy Cajun and Creole cuisine, Memphis barbecue, and explore the South’s rich history, culture, and music.

Experience a 9-day cruise aboard American Heritage from Memphis to New Orleans, discovering historic sites, Civil War stories, and charming towns along the Mississippi River. Experience rich history, music, and southern hospitality.

Experience a 9-day cruise aboard American Melody from Memphis to New Orleans, discovering historic sites, Civil War stories, and charming towns along the Mississippi River. Experience rich history, music, and southern hospitality.

Set sail on a 12-day Mississippi river cruise aboard the American Symphony, from New Orleans to Memphis, visiting Southern landmarks like Oak Alley, Houmas House, and Vicksburg National Military Park. Explore Baton Rouge's history, Natchez's antebellum homes, and Cleveland's musical heritage.

Set sail on a 9-day cruise on the American Symphony from Memphis to Nashville, traversing the Mississippi, Ohio, and Cumberland rivers—Immerse in local music, nightly entertainment, and Southern cuisine amid America's heartland's scenic beauty.