Top Mississippi River Trips & Tours in October 2027

The American Heritage hosts this 8-day Mississippi River cruise from New Orleans. Explore historic plantations, Civil War sites, and charming towns. Immerse in the rich culture, cuisine, and music of the Deep South.

Explore the segment of the Mississippi River on this 9-day cruise from St. Louis to Minneapolis American Melody. Begin in St. Louis, Missouri, and through Alton, Hannibal, Muscatine, Dubuque, Winona, and Red Wing. Visit Mark Twain's boyhood home, explore historic towns, and marvel at the diverse landscapes.

Experience a 9-day cruise aboard American Heritage from Memphis to New Orleans, discovering historic sites, Civil War stories, and charming towns along the Mississippi River. Experience rich history, music, and southern hospitality.

Experience a 9-day cruise aboard American Heritage from Memphis to New Orleans, discovering historic sites, Civil War stories, and charming towns along the Mississippi River. Experience rich history, music, and southern hospitality.

Experience a 9-day cruise aboard American Heritage from New Orleans to Memphis, discovering historic sites, Civil War stories, and charming towns along the Mississippi River. Experience rich history, music, and southern hospitality.

Set sail on a 9-day cruise on the American Symphony from Memphis to Nashville, traversing the Mississippi, Ohio, and Cumberland rivers—Immerse in local music, nightly entertainment, and Southern cuisine amid America's heartland's scenic beauty.