Top South America Trips & Tours in May 2025

On this 3-day extension tour of Uruguay, discover the alpine landscape of northern Maldonado, Uruguay, that once intrigued Charles Darwin. Explore rolling hills, picturesque valleys, and western sunrises. Take the scenic Route 12 for spectacular hill vistas. Uncover the charm of Pueblo Eden and the "Caracoles" and "Carape" Hills on this trip.

Explore 8 days of relaxing and fun aboard Samba yacht! Visit Genovesa, Isabela, Marchena, Fernandina, Floreana, Santa Cruz. Discover wildlife and the incredible landscapes of the Galapagos Islands!

Spend three days in Brazil's iconic Rio de Janerio, where you'll visit Corcovado and Sugarloaf, the two iconic peaks, and stroll the beaches of Ipanema and Copacabana. Spend a day exploring Manaus, the entrance of the Brazilian Amazon, before your 4-day Amazon adventure based out of the floating Eco-lodge, Uakari.

This 4-day Amazon cruise of Iquitos & Nauta aboard La Perla gives you an insider's view of life in Peru's rainforest, including piranha fishing, wildlife spotting, visit local villages, and opportunities to learn about wildlife preservation!

Embark on a private 8-day Hermes Ultra Luxury Cruise in the Northwestern Galapagos Islands. Explore unique wildlife, including giant tortoises and lava tunnels. Visit Cerro Dragón, Chinese Hat, Genovesa, and more. Enjoy birdwatching, snorkeling, and diverse wildlife encounters. Finally, visit North Seymour before heading to Baltra for your flight home.

Join the 7-Day Hermes Ultra Luxury Cruise in the Eastern & Central Galapagos, beginning on San Cristóbal Island. Explore Tijeretas, Gardner Bay, Punta Suárez, and Floreana. Snorkel at Champion Islet, then visit Genovesa Island. Conclude at Black Turtle Cove, disembarking in Baltra, marking the end of your unforgettable journey.

Embark on an unforgettable Amazon River cruise aboard Delfin III from Iquitos to Pacaya Samiria. Explore lush rainforests, encounter exotic wildlife, visit local communities, and relax in luxury aboard the Delfin.

Board the expeditionary river boat Tucano for a 5-day exploration of Brazil's Amazon rainforest along the Rio Negro. You will have daily opportunities to venture deep into the heart of the jungle as you tour the flooded forest of Igapo, visit indigenous communities and partake in their customs & traditions, and watch out for the incredible biodiversity.

This 15-day cruise covers all the unique wonders of the archipelago including Santa Cruz, Bartolome, Santiago, Isabela, Fernandina, North Seymour, Santa Fe, South Plaza, San Cristobal, Española, and Floreana Islands. Encounter Galapagos giant tortoises, penguins, frigatebirds, blue-footed boobies, sea lions, and more native species.

Enjoy the beauty of Bartolome, Española, Floreana, Mosquera Islet, North Seymour, San Cristobal, Santa Cruz, Santa Fe, Santiago and South Plaza on this 8-day Galapagos cruise aboard the M/C Endemic. On this cruise of the South and Central Islands, you'll have daily opportunities to hike, snorkel, kayak, and explore the incredible biodiversity of Galapagos!

This Galapagos cruise aboard the Tip Top IV takes you beyond the highlights of the Western Islands with 8 days of exciting activity! Enjoy the company of friendly sea lions while snorkeling and make friends with the gentle giant tortoises in Isabela and Santa Cruz.

Take in the sights, sounds, food, and culture as you explore Santiago, Buenos Aires, and Rio de Janeiro. This 10 day itinerary includes free days and optional activities so you can set the pace of your South American vacation!

Spend 5 days touring the western vineyards of Uruguay while exploring Colonia del Sacramento with its rich cultural heritage and the charming area of Carmelo. Visit multiple wineries and taste their own varieties of wine.

This 4-day Amazon cruise of Iquitos & Nauta aboard Amatista gives you an insider's view of life in Peru's rainforest, including piranha fishing, wildlife spotting, visit local villages, and opportunities to learn about wildlife preservation!

Adventure Life's guides and partners has identified the poorest families in the Cachiccata community. The elements can cause damage to homes over time, and many families do not have the extra means to make renovations to their homes. During this 4 day/3 night trip, participants, side-by-side with the family members, will work on cleaning, repairing, and restoring their homes. We stay in the community campground each night to immerse ourselves in the village life. The trip ends with traditional Inca ceremony and offering as a time to reflect over the previous days' experiences.

This week-long river cruise onboard La Perla is ideal for flora and fauna enthusiasts who want to experience the Amazon rainforest. This region of the world is a birding enthusiast's paradise. Also, witness pink river dolphins in a way you've never seen them before.

Take the opportunity to meet Argentina’s capital city, Buenos Aires! Often referred to as one of South America’s (and maybe the world’s) most exciting cities, Buenos Aires offers fabulous food, world famous wine, the Tango, amazing art, interesting neighborhoods. The city is interesting by day, and captivating by night.