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South America Fly + Cruise Adventures

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Cruise South America on one of these 15 flight and cruise combination trips selected by Adventure Life. These trips usually include a flight one way and a cruise the other way, which is a good option if you want to see more of South America in less time. Popular activities on these fly-cruise trips include Wildlife Viewing, Whale Watching, Kayaking, Photography Seminars, and Snorkeling.Trips to South America in 2025 start at $4,995 to $94,799 for 6 to 22 days-day itineraries. Let us know what kind of experience you're looking for in South America, and an Adventure Life travel specialist can help you plan the right trip.
 
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    • South America
Incredible ice formations
from $4,995
EXPLORE

Antarctica Express Air Cruise

6 Day Itinerary aboard Ocean Nova
  • Visit the legendary Cape Horn
  • Attend presentations and lectures
  • Sail through ice-filled bays
  • Explore Antarctic bases & stations
Starts / Ends
Port of Ushuaia / Punta Arenas
Activity Level
Variable
The fastest possible trip to Antarctica, and one of most economical is this 6-day cruise/flight starting in Ushuaia. Sail the Beagle Channel, Cape Horn, and mythical Drake Passage to experience a day in one of the most spectacular places on earth - Antarctica! Return on a flight from King George Island to Patagonia's Punta Arenas, Chile.
Cruise Details
0
from $12,995
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Magellan Discoverer Inaugural Air-Cruise

Roundtrip Punta Arenas - 10 Day Itinerary aboard Magellan Discoverer
  • Start your adventure in Punta Arena
  • Enjoy Patagonia Adventures
  • Beagle Channel and Drake Passage
  • Antarctic Exploration
  • Return Flight from King George Isla
Starts / Ends
Punta Arenas / Punta Arenas
Activity Level
Variable
Embark on a 10-day cruise on the Magellan Discoverer from Punta Arenas to Antarctica. Sail the Strait of Magellan, explore Glacier Alley, and cross the Drake Passage to the South Shetland Islands and Antarctic Peninsula. Spend three days discovering fjords, icebergs, and wildlife before flying back from King George Island.
Cruise Details
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Air transportation
from $5,995
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Antarctica Express Air Cruise

Ushuaia - Punta Arenas - 6 Day Itinerary aboard Magellan Explorer
  • Visit the legendary Cape Horn
  • Attend presentations and lectures
  • Sail through ice-filled bays
  • Explore Antarctic bases & stations
Starts / Ends
Port of Ushuaia / Punta Arenas
Activity Level
Variable
The shortest possible trip to Antarctica is this 6-day cruise/flight starting in Ushuaia, through the Beagle Channel, legendary Cape Horn, and mythical waters of the Drake Passage to experience a day in one of the most spectacular places on earth - Antarctica! Return on a flight from King George Island to Patagonia's Punta Arenas, Chile.
Cruise Details
0
from $6,795
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Antarctica Express Air Cruise

Punta Arenas - Ushuaia - 6 Day Itinerary aboard Magellan Discoverer
  • Visit the South Shetland Islands
  • Drake Passage navigation
  • Explore Puerto Williams
  • Chance to visit Cape Horn
Starts / Ends
Punta Arenas / Port of Ushuaia
Activity Level
Variable
The Antarctica Express Air cruise is a compact 6-day expedition. Begin in Punta Arenas, Chile, with a flight to King George Island to explore penguin colonies, ice-filled bays, and Antarctic wildlife. Sail through the Drake Passage, spot seabirds and whales, and, weather permitting, land at Cape Horn. Conclude in Ushuaia, Argentina.
Cruise Details
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A humpback whale dives beneath the Antarctic waters
from $16,195
Save 10%
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Antarctic Express: Sail South, Fly North

Buenos Aires - Punta Arenas - 10 Day Itinerary aboard World Voyager
  • Witness Antarctic wildlife
  • Fly over the Drake Passage
  • Visit research stations
  • Experience thrilling Zodiac rides
  • Witness massive icebergs
Starts / Ends
Port of Ushuaia / Punta Arenas
Activity Level
Variable
Embark on a 10-day Antarctic Express: Cruise South, Fly North Expedition aboard World Voyager. Antarctic cruise, exploring Ushuaia, the Drake Passage, and the Antarctic Peninsula. Encounter penguins, whales, and breathtaking ice landscapes on this once-in-a-lifetime adventure.
Cruise Details
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Watching Leopard Seal during Antarctic Cruise
from $17,895
EBD
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Antarctic Explorer - Fly/Sail Expedition

Punta Arenas - Ushuaia - 12 Day Itinerary aboard Sylvia Earle
  • Explore Punta Arenas’ rich history
  • Spot Antarctic wildlife
  • Sail the legendary Drake Passage
  • Witness Cape Horn
Starts / Ends
Punta Arenas / Ushuaia
Activity Level
Variable
Embark on a 12-day expedition cruise aboard the Sylvia Earle to explore Antarctica's stunning landscapes and unique wildlife, including penguins and whales. Enjoy enhanced exploration with a flight across the Drake Passage, maximizing your adventure in this pristine, ice-covered wilderness.
Cruise Details
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1800's whaling station
from $29,395
EBD
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South Georgia, Falklands & Antarctic Odyssey

Ushuaia - Punta Arenas - 20 Day Itinerary aboard Sylvia Earle
  • Discover Falklands’ beaches
  • Marvel at South Georgia’s glaciers
  • Spot Antarctica's wildlife
  • Explore Ushuaia’s rugged landscapes
Starts / Ends
Port of Ushuaia / Punta Arenas
Activities
Scuba Diving
Activity Level
Variable
Join a 20-day cruise on the Sylvia Earle, exploring Ushuaia, the Falklands, South Georgia, and Antarctica. Experience stunning landscapes, diverse wildlife, and expert-led activities, concluding with a flight from King George Island to Punta Arenas.
Cruise Details
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Two Glacier Mountains symmetrically reflecting in the Antarctic water
from $18,695
EBD
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Antarctica: Through the Lens - Fly/Sail Expedition

Punta Arenas - Ushuaia - 12 Day Itinerary aboard Greg Mortimer
  • Fly over the Drake Passage
  • Explore Punta Arenas vibrant scene
  • Spot Antarctic icebergs
  • Photograph glaciers and icebergs
Starts / Ends
Punta Arenas / Ushuaia
Activity Level
Variable
Join a 12-day Antarctic Explorer Fly/Sail Expedition from Punta Arenas to Ushuaia on the Greg Mortimer. Discover stunning wildlife, majestic glaciers, and pristine landscapes as you cruise through the Antarctic Peninsula's icy bays.
Cruise Details
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Albatross nest amid rolling hills in Falkland Islands
from $20,395
EBD
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Antarctic Explorer - Fly/Sail Expedition

Punta Arenas - Ushuaia - 12 Day Itinerary aboard Douglas Mawson
  • Join a Fly/Sail cruise expedition
  • Spot Antarctic wildlife
  • Witness Antarctic Peninsula glacier
  • Watch whales in Antarctic waters
Starts / Ends
Punta Arenas / Ushuaia
Activity Level
Variable
Embark on the 12-day Antarctic Explorer - Fly/Sail Expedition from Punta Arenas to Ushuaia aboard the Douglas Mawson. Fly over the Drake Passage to maximize your time exploring the Antarctic Peninsula. Experience vast glaciers, penguins, seals, and whales. Take Zodiac cruises, photograph icebergs, and witness skuas.
Cruise Details
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Penguins on the shores of Antarctica
from $32,295
EBD
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South Georgia, Falklands & Antarctic Odyssey

Ushuaia - Punta Arenas - 20 Day Itinerary aboard Sylvia Earle
  • Discover Falklands’ beaches
  • Marvel at South Georgia’s glaciers
  • Spot Antarctica's wildlife
  • Explore Ushuaia’s rugged landscapes
Starts / Ends
Port of Ushuaia / Punta Arenas
Activities
Snorkeling, Kayaking, Photography Seminars
Activity Level
Variable
Join a 20-day cruise on the Sylvia Earle, exploring Ushuaia, the Falklands, South Georgia, and Antarctica. Experience stunning landscapes, diverse wildlife, and expert-led activities, concluding with a flight from King George Island to Punta Arenas.
Cruise Details
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The beautiful Antarctica!
from $13,999
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Drake Fly & Sail

Ushuaia to King George Island - 11 Day Itinerary aboard World Traveller
  • Navigate Drake Passage
  • Discover remote Antarctic Peninsula
  • Spot penguins at Paulet Island
  • Explore glaciers and wildlife
Starts / Ends
Buenos Aires / Punta Arenas
Activities
Wildlife Viewing, Whale Watching, Local Market Visits
Activity Level
Variable
Embark on an 11-day Antarctica Drake Fly & Sail cruise aboard World Traveller. Sail across the Drake Passage, and explore the Antarctic Peninsula, Antarctic Sound, and South Shetland Islands. Make flexible landings based on ice and weather, guided by expert navigation.
Cruise Details
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Emperor penguin chick in Antarctica
from $13,395
Save 10%
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Antarctic Express: Fly South, Sail North

Punta Arenas - Buenos Aires - 9 Day Itinerary aboard World Voyager
  • Fly to King George Island
  • Spot whales and penguins
  • Cross the legendary Drake
  • Experience thrilling Zodiac rides
  • Cruise the Antarctic Peninsula
Starts / Ends
Punta Arenas / Buenos Aires
Activities
Hiking, Stand Up Paddle Boarding, Small Ship Sailing
Activity Level
Variable
Explore the Antarctic on this 10-day Antarctic Express: Fly South, Sail North cruise from Punta Arenas to Ushuaia aboard World Voyager. Explore the breathtaking Antarctic Peninsula and the South Shetland Islands, where you'll encounter towering glaciers, massive icebergs, and diverse wildlife, including penguins, whales, and seals.
Cruise Details
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Mirror-smooth waters in the Lemaire Channel
from $21,734
Savings
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Antarctica, South Georgia and the Falklands

Roundtrip Buenos Aires - 22 Day Itinerary aboard National Geographic Endurance
  • Admite Antarctica's unique beauty
  • Observe spectacular wildlife
  • Discover three different regions
  • Enjoy incredible photo ops
Starts / Ends
Buenos Aires / Santiago
Activity Level
Variable
This extraordinary 22-day Antarctica expedition takes you to Antarctica, South Georgia, and the Falkland Islands. Enjoy an extra day at the Peninsula by flying from the Falkland Islands back to the mainland. Take full advantage of rare wildlife sightings, watching whales feed off the bow or perfect conditions for a late day kayaking excursion.
Cruise Details
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Brilliant blue icebergs in Antarctic waters
from $18,595
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Voyaging Beyond the Antarctic Circle

Ushuaia - Ushuaia - 14 Day Itinerary aboard Le Lyrial
  • Discover rare polar sights
  • Learn from expert guides
  • Witness stunning glaciers
  • Uncover Shackleton’s Historic Sites
Starts / Ends
Buenos Aires / Ushuaia
Activities
Village Visits, Archaeological Site Visits
Activity Level
Variable
Venture on a 14-day Antarctica cruise that starts in Buenos Aires and sails from Ushuaia aboard Le Lyrial. Cross the famous Drake Passage, take daily Zodiac trips, see penguins and whales up close, and explore Antarctica with A&K’s expert guide, plus a chance to cross the Antarctic Circle.
Cruise Details
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Spot king penguins in subantarctic islands
from $21,734
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Antarctica, South Georgia, and the Falklands

Roundtrip Santiago, Chile - 22 Day Itinerary aboard National Geographic Resolution
  • Marvel at a king penguin colony
  • Experience Antarctic ice
  • See incredible wildlife
  • Travel to three distinct regions
Starts / Ends
Santiago / Santiago
Activity Level
Variable
Marvel at vast colonies of penguins, spot majestic whales, look for a variety of species of seals, and watch soaring sea birds. Explore rugged, untouched landscapes, and be humbled by massive icebergs and mountains. The ultimate Southern Ocean experience, this unforgettable 22-day expedition cruise takes you into spectacular wilderness.
Cruise Details
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