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Historic Zurich with River Limmat, Switzerland

Top Switzerland Trips & Tours in September 2025

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Discover Switzerland in September 2025 on one of these 31 tours hand-selected by the travel experts at Adventure Life. Explore the best of during September 2025 as you enjoy Biking, Hiking, Wine Tasting, Village Visits, and Land & Sea Exploration. Prices for trips in September 2025 range from $3,382 to $19,190 for a vacation of 8 to 15 days. Choose any of the below 31 itineraries in September 2025 and customize it when you contact one of Adventure Life's expert Switzerland trip planners.
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Heidelberg
from $7,399
EXPLORE

Rhine & Moselle Delights

15 Day Itinerary aboard MS Amaprima
  • Cruise tranquil Lake Lucerne
  • Explore Strasbourg on foot
  • Visit Trier, Germany’s oldest city
  • Admire Amsterdam's beauty
Activity Level
Variable
This 15-day Rhine & Moselle River cruise aboard MS Amaprima takes you from Zurich to Basel to Amsterdam, passing through Germany and France along the way. Hike and bike in the lush Rhine Valley, stroll the "Crossroads of Europe" in Strasbourg, and savor the best wines and beers that have made this region famous.
Cruise Details
0
French Alpine village of Les Contamines-Montjoie
from $11,187
EXPLORE

Mount Blanc Hiking Adventure

10 Day Itinerary
  • Enjoy the view of Chamonix
  • Hike the Mont Blanc
  • Admire the Bioniassay glacier
  • Explore Courmayeur Alpine resort
  • Hike the old trail valley in Trient
Starts / Ends
Geneva / Geneva
Activities
Wilderness Lodge Exploration
Activity Level
Challenging
On this 10-day tour, hike through the stunning Mont Blanc mountain range between Italy and France to see the panoramic vistas, beautiful mountain huts, and serene lakes and pass through enchanting mountain villages.
Tour Details
0
Stop in beautiful Basel, Switzerland
from $5,099
EXPLORE

Castles along the Rhine

Basel - Amsterdam - 8 Day Itinerary aboard S.S. Antoinette
  • Discover Alsatian wine villages
  • Visit Marksburg Castle in Koblenz
  • Savor Rieslings at Castle Vollrads
  • Explore Cologne's historic center
Starts / Ends
Basel / Amsterdam
Activities
Urban Exploration
Activity Level
Variable
Embark on an 8-day Rhine River cruise from Basel to Amsterdam aboard the S.S. Antoinette. Discover the charm of medieval towns like Breisach and Braubach, explore the cobbled streets of Strasbourg, and visit the majestic Marksburg Castle. Delight in guided walking tours, bike rides along the Rhine, and panoramic views from cable cars.
Cruise Details
0
La Petite district in Strasbourg
from $3,599
EXPLORE

Rhine Getaway

Amsterdam to Basel - 8 Day Itinerary aboard Viking River Cruises
  • Explore the village of Kinderdijk
  • View the sites of Rüdesheim
  • Discover the Speyer Cathedral
  • Visit resplendent churches
Starts / Ends
Amsterdam / Basel
Activity Level
Variable
Explore one of Europe’s best-loved rivers, the Rhine, during this 8-day voyage. Discover the turreted fortresses, grand cathedrals, historic cities, medieval towns and spectacular scenery of the Middle Rhine - a UNESCO World Heritage Site. From Amsterdam to Basel, this journey reveals a rich landscape of beauty and culture.
Cruise Details
0
Historic Zurich with River Limmat, Switzerland
from $6,499
EXPLORE

Enchanting Rhine

Zurich - Amsterdam - 12 Day Itinerary aboard MS Amastella
  • Wander Strasbourg’s charming street
  • Discover Basel’s historical gems
  • Stroll medieval walls in Lucerne
  • Explore Zurich’s vibrant history
Activity Level
Variable
Sail the Rhine on a 12-day cruise with stays in Zurich and Lucerne aboard the MS Amastella. Explore vibrant cities, storybook towns, and a UNESCO-listed landscape of castles, breweries, and timeless traditions.
Cruise Details
0
Explore Basel
from $6,499
EXPLORE

Enchanting Rhine

Zurich - Amsterdam - 12 Day Itinerary aboard MS Amacerto
  • Explore Zurich's vibrant history
  • Wander Strasbourg's streets
  • Visit Breisach's countryside
  • Cruise Rhine's stunning castles
Starts / Ends
Zurich / Amsterdam
Activity Level
Variable
Set sail from Zurich to Amsterdam on a 12-day Rhine cruise aboard the MS Amacerto. Discover vibrant cities, storied towns, and timeless traditions amid stunning castles and scenic riverbanks.
Cruise Details
0
Schloss Neuschwanstein overlooks the green countryside
from $6,499
EXPLORE

Enchanting Rhine

Zurich - Amsterdam - 12 Day Itinerary aboard MS Amaviola
  • Explore Cologne’s Old Town
  • Experience Dusseldorf, a city rich
  • Enjoy Dutch specialties
  • Visit Heidelberg’s historic sites
Activity Level
Variable
Embark on a 12-day cruise with stays in Zurich and Lucerne aboard the MS Amaviola, where vibrant cities and charming towns reveal rich histories. Sail along the Rhine's UNESCO World Heritage stretch, featuring stunning castles and delightful villages.
Cruise Details
0
Discover the history and art of Barcelona
from $7,824
EXPLORE

Essence of Burgundy & Provence

14 Day Itinerary aboard MS Amacello
  • Discover Geneva’s vibrant history
  • Explore Annecy’s picturesque charm
  • Stroll Dijon’s medieval streets
  • Visit Tournus’ Benedictine abbey
Starts / Ends
Geneva / Nice
Activities
Archaeological Site Visits, Local Market Visits
Activity Level
Variable
Embark on a 14-day cruise aboard the Amacello through Switzerland and France, from Geneva and Annecy through Burgundy and Provence. Indulge in Lyon’s culinary delights, explore historic treasures, and end with three unforgettable nights in Nice, Monaco, and Monte Carlo.
Cruise Details
0
Rhine Gorge
from $7,329
EXPLORE

Captivating Rhine

Amsterdam - Zurich - 14 Day Itinerary aboard MS Amastella
  • Walk Dusseldorfs charming streets
  • Explore Heidelbergs grand castle
  • Discover Strasbourgs charm
  • Sail through the Rhine Gorge
Activity Level
Variable
Sail the legendary Rhine on a 14-day cruise with stays in Amsterdam, Lucerne, and Zurich. Explore vineyard-lined hills, storybook towns, and the charm of Alsace, ending with the stunning Swiss Alps.
Cruise Details
0
Strasbourg
from $7,329
EXPLORE

Captivating Rhine

14 Day Itinerary aboard MS Amaviola
  • Join a guided bike tour
  • Visit Speyer
  • Enjoy Parc de l’Orangerie
  • Explore the Black Forest
Activity Level
Variable
From Amsterdam’s colorful canals to the majestic Swiss Alps, enjoy a 14-day exploration of the Rhine Valley, starting with two days in Amsterdam followed by 7 nights aboard the MS Amaviola, and concluding with four nights in Switzerland between Lucerne and Zurich. Sample the local brews of beer and coffee with chances to hike and bike as well!
Cruise Details
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Rhine Gorge
from $7,329
EXPLORE

Captivating Rhine

Amsterdam - Zurich - 14 Day Itinerary aboard MS Amalucia
  • Taste wines in Rudesheim’s vineyard
  • Bike through charming Strasbourg
  • Explore Dusseldorf’s vibrant street
  • Wander Colmar’s fairytale alleys
Starts / Ends
Amsterdam / Zurich
Activities
Land & Sea Exploration
Activity Level
Variable
Sail the legendary Rhine on this 14-day river cruise aboard the MS Amalucia, where vineyard-clad hills and fairy-tale castles set the scene. Explore charming Alsace, historic German towns, and Amsterdam’s canals, savoring local flavors and unforgettable landscapes.
Cruise Details
0
Ehrenfels Castle on Rhine River near Rudesheim
from $4,639
EXPLORE

Enchanting Rhine - Cruise Only

Basel - Amsterdam - 8 Day Itinerary aboard MS Amalucia
  • Explore Heidelberg's castle views
  • Savor Rudesheim's famed Riesling
  • Stroll Strasbourg's streets
  • Discover Breisach's scenic past
Starts / Ends
Basel / Amsterdam
Activity Level
Variable
Embark on an 8-day river cruise aboard the MS Amalucia, exploring cities where rich history meets modern progress. Journey along the scenic Rhine, passing 40 castles, timeless traditions, and inspiring towns like Heidelberg, where Mark Twain wrote A Tramp Abroad.
Cruise Details
0
View of Strasbourg city
from $4,639
EXPLORE

Enchanting Rhine - Cruise Only

8 Day Itinerary aboard MS Amastella
  • See Strasbourg's Gothic Cathedral
  • Enjoy Heidelberg's natural beauty
  • Hike through Rüdesheim
  • Admire Amsterdam's canals
Activity Level
Variable
From Basel, Switzerland to Amsterdam, the Netherlands, this classic 8-day cruise of the Rhine & Moselle Rivers aboard the MS Amastella will take you through scenic wine country, where you can visit, hike, and tour the historic towns, museums, and canals of Breisach, Strasbourg, Manheim & Heidelberg, the castles of Rüdesheim, and Koblenz & Cologne.
Cruise Details
0
Cruise the rivers of Germany
from $8,190
2-for-1
EXPLORE

Jewels of the Rhine

Zurich - Amsterdam - 8 Day Itinerary aboard Emerald Sun
  • Visit a Black Forest village
  • Visit Heidelberg Castle
  • Take a walk to Heidelberg
  • Ride a cable car in Koblenz
Starts / Ends
Zurich / Amsterdam
Activity Level
Variable
From Zurich to Amsterdam, the Emerald Sun invites you on this mesmerizing 8-day Rhine River cruise, visiting Basel, Breisach, Cologne, Heidelberg, Koblenz, Mannheim, and Strasbourg. Each day, you can choose how you'd like to explore each of these historic cities, with chances for hiking, biking, and walking tours.
Cruise Details
0
Cochem
from $4,639
EXPLORE

Rhine & Moselle Splendors - Cruise Only

Luxembourg - Basel - 8 Day Itinerary aboard MS Amacerto
  • Explore Cochem’s historic castle
  • Cruise Rhine Gorge’s beauty
  • Visit Heidelberg's treasure
  • Taste Rudesheim’s unique coffee
Starts / Ends
Luxembourg / Basel
Activities
Wine Tasting, Hiking, Biking, Village Visits
Activity Level
Variable
Embark on an 8-day river cruise aboard the MS Amacerto. Discover Roman treasures, enchanting folklore, and cultural gems like Strasbourg and Schwetzingen Palace Gardens on this unforgettable journey.
Cruise Details
0
Trier
from $5,539
EXPLORE

Rhine & Moselle Delights - Cruise Only

11 Day Itinerary aboard MS Amaprima
  • Explore “La Petite France”
  • Bike along the Rhine River
  • Discover Porta Nigra's secrets
  • Enjoy the fairytale town of Cochem
Starts / Ends
Basel / Amsterdam
Activity Level
Variable
Begin this exclusive 11-day cruise in Basel and conclude in charming Amsterdam. This voyage includes a large variety of activities so that you can choose how you want to explore the wondrous delights of the Rhine and Moselle River regions.
Cruise Details
0
River through Koblenz Germany
from $3,382
EXPLORE

From Basel to Amsterdam: The Treasures of the Celebrated Rhine River

8 Day Itinerary aboard MS Symphonie
  • Visit the spectacular Rhine Falls
  • Enjoy a free morning in Breisach
  • Admire the wine-growing region
  • Explore the Gutenberg Museum
Starts / Ends
Basel / Amsterdam
Activity Level
Variable
Explore the enchanting waterways of the Rhine River aboard the comfortable MS Symphonie. Discover a mix of nature and culture on this 8-day voyage from the Three Countries Bridge to Holland, with stops at the Gutenberg Museum, the Strasbourg wine-growing region, and the Rhine Falls, as well as Cologne, Mainz, and Xanten.
Cruise Details
0
Visit beautiful and historic Strasbourg
from $7,119
EXPLORE

Rhine Castles & Swiss Alps

13 Day Itinerary aboard MS Amaserena
  • Discover Amsterdam’s charming canal
  • Explore Cologne’s historic treasure
  • Cruise Rhine Gorge’s castles
  • Visit Rudesheim’s scenic vineyards
Starts / Ends
Amsterdam / Basel
Activity Level
Variable
Sail aboard the MS Amaserena on a 13-day cruise through Europe, featuring Amsterdam’s canals, Germany’s Rhine Gorge castles, France’s Alsace charm, and Italy’s glamorous Lake Como. Explore five countries and iconic landmarks.
Cruise Details
0
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