Have questions? We're here.
Park Guell, unique houses designed by Gaudi in Barcelona

Top Spain Trips & Tours in September 2025

Travel made your way ™
Talk with an expert
Build your ideal Spain trip. Call 1.406.541.2677
Start Planning My Trip
Talk with an expert
Discover Spain in September 2025 on one of these 17 tours hand-selected by the travel experts at Adventure Life. Explore the best of Pinhão, Regua, Porto, Vega de Terron, and Salamanca during September 2025 as you enjoy cruises, wine tasting, river cruises, luxury, and food & wine. Prices for trips in September 2025 range from $1,480 to $28,690 for a vacation of 8 to 15 days. Choose any of the below 17 itineraries in September 2025 and customize it when you contact one of Adventure Life's expert Spain trip planners.
Filter (17 Results)
  • Start Date
    OR, More specific start
  • Length
    to
  • Price
    to
  • Activity Level
  • Experiences
  • Activities
  • Ships
  • Destinations
    • Spain
Porto Cityscape, Portugal
$3,699
EXPLORE

Flavors of Portugal & Spain - Cruise Only

8 Day Itinerary aboard MS Amavida
  • Explore Porto's historic old town
  • Taste Portugal's wines
  • Visit Nossa Senhora dos Remédios
  • Hike through Vega Terron, Spain
Activities:
Hiking, Small Ship Cruises, Village Visits, Wine Tasting
Activity Level:
Variable
Start your adventure in the city of Porto and learn more about its rich history while visiting sites such as Palacio de Mateus, located in the beautiful region of Trás-os-Montes near the city of Vila Real. The interior of the house features various religious images and exquisite furniture, …
Cruise Details
0
Salamanca, Spain
$3,699
Savings
EXPLORE

Enticing Douro

Roundtrip Porto - 8 Day Itinerary aboard MS Amadouro
  • Tour the São Bento Railway Station
  • Sample Bôlas de Lamego
  • Visit Salamanca
  • Visit the Palacio de Mateus
Starts / Ends:
Porto / Porto
Activities:
Hiking, Land & Sea Exploration, Wine Tasting
Activity Level:
Variable
Visit Porto, the beautiful “City of Bridges,”; and Salamanca, the “Golden City,” on this 8-day Douro River cruise on MS Amadouro. Taste wines from historic wineries and soak up the genuine beauty of one of Europe’s most unadulterated landscapes. Rambling vineyards and …
Cruise Details
0
Porto with Dom Luis Bridge
$4,689
EXPLORE

Enticing Douro

11 Day Itinerary aboard MS Amadouro
  • Tour Belem Tower
  • Explore the Castelo da Pena
  • Travel to Lamego
  • Enjoy Sandeman Winery
Starts / Ends:
Lisbon / Regua
Activities:
Hiking, Land & Sea Exploration, River Cruises, Wine Tasting
Activity Level:
Variable
Rambling vineyards and charming native farms cling to the steep sides of the Douro River Valley, creating an incomparable backdrop to one of Europe’s most unspoiled regions and to Port country — the world’s oldest demarcated wine region. Visit Porto, the beautiful “City of …
Cruise Details
0
Explore historic Porto
$10,190
EXPLORE

Delightful Douro

Porto Roundtrip - 8 Day Itinerary aboard Scenic Azure
  • Explore the Douro Museum in Regua
  • Enjoy the elegant town of Lamego
  • Visit Salamanca
  • Be amazed by the Côa Valley Museum
Starts / Ends:
Porto / Porto
Activities:
Local Market Visits, River Cruises, Village Visits
Activity Level:
Variable
From windswept seaside meanderings to the astonishing beauty of the Douro Valley, this is a journey of contemplation and elegance. In Porto, board the luxurious Scenic Azure, which will transport through the hidden gems of the Douro Valley. Days will be spent immersed in the proud history and …
Cruise Details
0
Porto Cityscape, Portugal
$5,499
EXPLORE

Douro River Valley

Roundtrip Porto - 8 Day Itinerary aboard S.S. Sao Gabriel
  • Wander Salamanca's ancient streets
  • Tour Braga's rich history
  • Visit Douro Museum
  • Tour Porto’s Ribeira
Starts / Ends:
Porto / Porto
Activities:
Archaeological Site Visits, River Cruises, Urban Exploration, Wine Tasting
Activity Level:
Variable
Embark on an 8-day cruise to and from Porto aboard the S.S. Sao Gabriel. Along the Douro River, cruising past Portugal's terraced hills, charming villages, and vineyards. Enjoy exclusive Port tastings, explore Porto's historic Ribeira district, and visit the UNESCO-listed Douro Valley. …
Cruise Details
0
Sprawling vineyards of France
$6,349
EXPLORE

Colors of Provence

14 Day Itinerary aboard MS Amakristina
  • Enjoy Lyon's culinary delights
  • Visit the Beaujolais wine region
  • Join a Provencal cooking lesson
  • Admire Antoni Gaudi’s works
Starts / Ends:
Paris / Barcelona
Activities:
Archaeological Site Visits, Biking, Cooking Classes, River Cruises, Urban Exploration, Wine Tasting
Activity Level:
Variable
Cruise through France’s legendary wine growing regions, home to such famous vintages as Beaujolais and Côte du Rhône. Enjoy wine tastings at local vintners, marvel at ancient Roman ruins, stroll through medieval villages, and shop for Provencal crafts. Visit the UNESCO World …
Cruise Details
0
Discover the history and art of Barcelona
$5,229
EXPLORE

Essence of Burgundy & Provence

14 Day Itinerary aboard MS Amacello
  • Visit Chillon Castle
  • Cooking class in Valence
  • Explore Tournus
  • Enjoy the “City of Gaudi” Barcelona
Starts / Ends:
Chalon Sur Saone / Barcelona
Activities:
River Cruises, Urban Exploration
Activity Level:
Variable
From romantic cities to foodie havens and artistic epicenters, this 14-day itinerary enlivens all your senses. Spend three nights in Geneva before going to Lyon, France’s culinary capital. Savor the beauty of legendary vineyards and imbibe in local vintages like Beaujolais and Côtes du …
Cruise Details
0
Waterways of Libourne
$6,504
EXPLORE

Taste of Bordeaux

15 Day Itinerary aboard MS Amadolce
  • Visit the Atrium
  • Tour Arcachon
  • Explore the Castle of Roquetaillade
  • Enjoy wine tasting
Activities:
Land & Sea Exploration, Wine Tasting
Activity Level:
Variable
Board the Amadolce and enjoy 2 nights in Bilbao and 2 nights in San Sebastian leading up to a 7-night roundtrip Bordeaux cruise, followed by 2 nights in the Loire Valley and 1 night in Paris. On your roundtrip Bordeaux cruise enjoy one of the world’s undisputed wine regions. Iconic …
Cruise Details
0
Visit the historic Belem tower near Lisbon
$9,015
EXPLORE

Secrets of the Douro & Lisbon

Porto - Lisbon - 11 Day Itinerary aboard Emerald Radiance
  • Visit Ruins of Lisbon
  • Experience Roman times.
  • Explore Douro Valley
  • Amaze with eclecticmix architecture
Starts / Ends:
Pinhão / Lisbon
Activities:
Archaeological Site Visits, River Cruises, Village Visits, Wine Tasting
Activity Level:
Variable
Start your journey in the Portuguese capital of Lisbon, where the cobbled alleyways and ancient ruins are yours to explore before meeting your Emerald Waterways Star-Ship in Porto. A symbol of Portugal’s birth and growth as a nation, the Douro has long been the country’s lifeline. …
Cruise Details
0
Porto with Dom Luis Bridge
$4,199
EXPLORE

Portugal's River of Gold

Lisbon-Porto - 10 Day Itinerary aboard Viking Cruises
  • Tour the Jerónimos Monastery
  • Visit Vila Real's Mateus Palace
  • Explore Castelo Rodrigo
  • Enjoy Salamanca, Spain
Starts / Ends:
Lisbon / Salamanca
Activities:
Archaeological Site Visits, River Cruises, Small Ship Cruises, Wine Tasting
Activity Level:
Variable
Take in the natural beauty and rich history of the Douro River. Experience Lisbon's renaissance, revitalized by trendy galleries and eateries. Explore two of Iberia's most historic university towns: Coimbra, Portugal, and Salamanca, Spain. Tour Porto's port warehouses and enjoy …
Cruise Details
0
Visit the town of Pinhao, in the heart of the beautiful Douro Valley
$2,635
EXPLORE

From Portugal to Spain: Porto, the Douro Valley (Portugal) and Salamanca (Spain)

8 Day Itinerary aboard MS Infante Don Henrique
  • Explore Porto
  • Discover Salamanca
  • Experience Vega de Terron
  • Discover Douro Valley
Activities:
River Cruises, Wine Tasting
Activity Level:
Variable
Embark on an 8-day cruise to and from Porto aboard the MS Infante Don Henrique. Cruise through the stunning Douro Valley, filled with breathtaking scenery, historic sites, and unique experiences. Start your journey in the vibrant city of Porto, then travel through Regua to explore the region's …
Cruise Details
0
Visit the historic Belem tower near Lisbon
$9,015
EXPLORE

Lisbon & Secrets of the Douro

Lisbon - Porto - 11 Day Itinerary aboard Emerald Radiance
  • Visit Ruins of Lisbon
  • Experience Roman times.
  • Explore Douro Valley
  • Amaze with eclecticmix architecture
Starts / Ends:
Lisbon / Porto Antigo
Activities:
Archaeological Site Visits, River Cruises, Village Visits, Wine Tasting
Activity Level:
Variable
Start your journey in the Portuguese capital of Lisbon, where the cobbled alleyways and ancient ruins are yours to explore before meeting your Emerald Waterways Star-Ship in Porto. A symbol of Portugal’s birth and growth as a nation, the Douro has long been the country’s lifeline. …
Cruise Details
0
Porto with Dom Luis Bridge
$1,480
EXPLORE

Portugal to Spain - Porto, the Douro Valley and Salamanca

8 Day Itinerary aboard MS Vasco de Gama
  • Admire the city of Porto at night
  • Tour Vila Real by coach
  • Explore the old city of Salamanca
  • Visit Lamego's monumental sanctuary
Activities:
River Cruises, Wine Tasting
Activity Level:
Variable
Be carried away by the charm of the Mediterranean countries. From Portugal to Spain, you will visit Porto, a lively and fascinating city where you can taste its famous wine, or Guimarães, the beating heart of Portugal with a remarkable history that gives it today all its charm. Be guided …
Cruise Details
0
Porto, Portugal Old Town
$8,290
EXPLORE

Secrets of the Douro

Porto - Porto - 8 Day Itinerary aboard Emerald Radiance
  • Visit Quinta do Tedo vineyard
  • Experience Roman times
  • Explore Douro Valley
  • Admire eclectic mix architecture
Starts / Ends:
Lisbon / Porto Antigo
Activities:
Archaeological Site Visits, River Cruises, Village Visits, Wine Tasting
Activity Level:
Variable
Start your voyage in Porto by boarding the Emerald Waterways Star-Ship. The Douro, a symbol of Portugal's origin and growth as a nation, has long served as the country's lifeblood. After leaving the pastel-colored city of Porto, travel across the enchanting countryside. The riverbanks are …
Cruise Details
0
The architectures of Lyon
$3,699
EXPLORE

Essence of Burgundy & Provence - Cruise Only

8 Day Itinerary aboard MS Amacello
  • Visit Chillon Castle
  • Cooking class in Valence
  • Explore Tournus
  • Enjoy the “City of Gaudi” Barcelona
Starts / Ends:
Chalon Sur Saone / Barcelona
Activities:
River Cruises, Urban Exploration
Activity Level:
Variable
Indulge in French flavors on a palate-pleasing 8-day river cruise that highlights the essence of France’s Burgundy and Provence. Uncover the Roman history of Chalon-sur Saône and delight in charming Tournus with its towering Romanesque abbey and historic apothecary shop. Visit French …
Cruise Details
0
Relax in beautiful Porto
$14,290
EXPLORE

The Unforgettable Douro

Porto to Porto - 11 Day Itinerary aboard Scenic Azure
  • Enjoy a Fado performance
  • Enjoy a variety of activities
  • Explore the Douro Museum
  • Tour charming villages
  • Taste locally-produced wines
Starts / Ends:
Porto / Porto
Activities:
Small Ship Cruises, Village Visits, Wine Tasting
Activity Level:
Variable
Portugal’s Douro River winds through stunning landscapes dotted with timeless towns that have preserved traditional ways of life. From elegant Lamego to Regua and Vega de Terron, find pockets of history and traditional living tucked amid the lush green hillsides of the Douro Valley. Board …
Cruise Details
0
Stop in sunny Salamanca
$11,240
EXPLORE

Delightful Douro with Lisbon

11 Day Itinerary aboard Scenic Azure
  • Visit the Maritime Museum
  • Visit Palacio Nacional
  • Relax and enjoy musical performance
  • Explore the Douro Museum in Regua
Starts / Ends:
Lisbon / Porto
Activities:
River Cruises, Small Ship Cruises, Wine Tasting
Activity Level:
Variable
Discover the beautiful Douro river valley with a relaxing adventure aboard Scenic Azure. Attend an exclusive Sundowners cocktail event on the manicured lawns of the Douro Museum, and watch as the sun sinks beneath the fruitful vines of Régua’s plentiful vineyards. Tour the …
Cruise Details
0
1-17 of 17 Results
TrustScore 4.8 | 378 reviews
TrustScore 4.8 of 5
total score
Based on 378 reviews on
review score
11 hours ago
I’m so glad we found AdventureLife. Jess, our planner, was such a pleasure to work with. She readily shared her extensive knowledge about Panama, she offered good suggestions and creative ideas, kept everything organized and handled the details each step of the way.
Tim King
review score
1 day ago
Jessica was wonderful! She made every effort to ensure our trip was just what we wanted.
Celine Krafft
review score
1 day ago
Erin was easy to work with and very helpful. She was patient and helped us figure out the adventure tour we were hoping for in Belize. Can’t wait to go on this trip!
Sam Wedll
review score
2 days ago
Jason has gone above and beyond. We have so much appreciation for him!
Jackie Smedley
review score
2 days ago
My travel planner, Jeff, who is on top of his field (based on travel industry awards), is a highly professional, very effective and, at the same time, personally nice individual. What was also critical to me is that he has a first hand experience traveling in the region that I am going to. On top of that, the customer relations director, Sarah, has personally followed up to make sure I'm happy.
alex shaykis

Spain Travel Guide

Top Spain Travel Destinations

Spain Trips by Departure Date

Top Experiences in Spain

Spain Trips by Duration

Spain Trips by Activity

More Reasons

Why Travel With Adventure Life

All News

Recognized By

Clara Tort Adventure Life employee profile
Clara T
Plan My Trip
We love travel, talk with an expert 1.800.344.6118