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Alcazar de Colon, Diego Columbus residence on Spanish Square. Tourists walk in Colonial Zone of the city Santo Domingo, Dominican Republic.

Santiago de los Caballeros Hotels & Lodging

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Browse the top picks for hotels, lodges, resorts, and accommodation in Santiago de los Caballeros for 2025-2026. Adventure Life's Santiago de los Caballeros travel experts have hand picked each of the below hotels because they have unique local flavor, provide excellent service, and serve as an excellent base as you explore Santiago de los Caballeros. Still can't decide on where the best place to stay in Santiago de los Caballeros is? No worries, contact one of our Santiago de los Caballeros travel experts and they'll help match you with the perfect lodging and the perfect trip to Santiago de los Caballeros.

Standard Hotels

The Standard Hotels are our primary hotel choices in this location, though availability is not guaranteed. If a given hotel is not available for your tour date, we will reserve you a room at a location of similar appeal and quality in the same area.

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